Pre-transplant immune profile defined by principal component analysis predicts acute rejection after kidney transplantation.

ABSTRACT:

Background

Acute rejection persists as a frequent complication after kidney transplantation. Defining an at-risk immune profile would allow better preventive approaches.

Methods

We performed unsupervised hierarchical clustering analysis on pre-transplant immunological phenotype in 1113 renal transplant recipients from the ORLY-EST cohort.

Results

We identified three immune profiles correlated with clinical phenotypes. A memory immune cluster was defined by memory CD4⁺T cell expansion and decreased naïve CD4⁺T cell. An activated immune cluster was characterized by an increase in CD8⁺T cells and a decreased CD4/CD8 ratio. A naïve immune cluster was mainly defined by increased naïve CD4⁺T cells. Patients from the memory immune

SUBMITTER: Gaiffe E 

PROVIDER: S-EPMC10367005 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature