Anti-MDA5-positive dermatomyositis and remission in a single referral centre population.

ABSTRACT:

Objectives

To describe a single-centre North American adult cohort of anti-MDA5-positive dermatomyositis patients, with emphasis on drug-free long-term remission.

Methods

We conducted an observational retrospective cohort study of anti-MDA5-positive DM patients. All consented patients seen in the Johns Hopkins Myositis Centre from 2003-2020 with suspected muscle disease were routinely screened for myositis-specific autoantibodies. All sera were screened for anti-MDA5 autoantibodies by line blot; positives were verified by enzyme-linked immunoassay. Patients whose sera were anti-MDA5 positive by both assays (n=52) were followed longitudinally. If clinical status was unavailable, structured telephone interviews were conducted. Clinical remission was defined as being off all im

SUBMITTER: Tiniakou E 

PROVIDER: S-EPMC10367060 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature