Healthy Aging and Cardiovascular Function: Invasive Hemodynamics During Rest and Exercise in 104 Healthy Volunteers.

ABSTRACT:

Objectives

The aim of this study was to evaluate the association between age and invasive cardiovascular hemodynamics during upright exercise among healthy adults.

Background

The marked age-related decline in maximal exercise oxygen uptake (peak VO₂) may contribute to the high burden of heart failure among older individuals and their greater severity of exertional symptoms. However, the mechanisms underlying this decline are not well understood.

Methods

A total of 104 healthy community-dwelling volunteers age 20 to 76 years well screened for cardiovascular disease underwent exhaustive upright exercise with brachial and pulmonary artery catheters; radionuclide ventriculography; and expired gas analysis for the measurement of peak VO₂, cardiac outp

SUBMITTER: Pandey A 

PROVIDER: S-EPMC10367061 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature