Application of AllerCatPro 2.0 for protein safety assessments of consumer products.

ABSTRACT: Foreign proteins are potentially immunogenic, and a proportion of these are able to induce immune responses that result in allergic sensitization. Subsequent exposure of sensitized subjects to the inducing protein can provoke a variety of allergic reactions that may be severe, or even fatal. It has therefore been recognized for some time that it is important to determine a priori whether a given protein has the potential to induce allergic responses in exposed subjects. For example, the need to assess whether transgene products expressed in genetically engineered crop plants have allergenic properties. This is not necessarily a straightforward exercise (as discussed elsewhere in this edition), but the task becomes even more challenging when there is a need to conduct an overall alle

SUBMITTER: Krutz NL 

PROVIDER: S-EPMC10367106 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature