MuLan-Methyl-multiple transformer-based language models for accurate DNA methylation prediction.

ABSTRACT: Transformer-based language models are successfully used to address massive text-related tasks. DNA methylation is an important epigenetic mechanism, and its analysis provides valuable insights into gene regulation and biomarker identification. Several deep learning-based methods have been proposed to identify DNA methylation, and each seeks to strike a balance between computational effort and accuracy. Here, we introduce MuLan-Methyl, a deep learning framework for predicting DNA methylation sites, which is based on 5 popular transformer-based language models. The framework identifies methylation sites for 3 different types of DNA methylation: N6-adenine, N4-cytosine, and 5-hydroxymethylcytosine. Each of the employed language models is adapted to the task using the "pretrain and fine-tune"

SUBMITTER: Zeng W 

PROVIDER: S-EPMC10367125 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature