CircRNA/lncRNA-miRNA-mRNA network and gene landscape in calcific aortic valve disease.

ABSTRACT:

Background

Calcific aortic valve disease (CAVD) is a common valve disease with an increasing incidence, but no effective drugs as of yet. With the development of sequencing technology, non-coding RNAs have been found to play roles in many diseases as well as CAVD, but no circRNA/lncRNA-miRNA-mRNA interaction axis has been established. Moreover, valve interstitial cells (VICs) and valvular endothelial cells (VECs) play important roles in CAVD, and CAVD differed between leaflet phenotypes and genders. This work aims to explore the mechanism of circRNA/lncRNA-miRNA-mRNA network in CAVD, and perform subgroup analysis on the important characteristics of CAVD, such as key cells, leaflet phenotypes and genders.

Results

We identified 158 differentially expressed circRNAs (DEcircRNAs

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC10367311 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature