The expression profiles of signature genes from CD103⁺LAG3⁺ tumour-infiltrating lymphocyte subsets predict breast cancer survival.

ABSTRACT:

Background

Tumour-infiltrating lymphocytes (TILs), including T and B cells, have been demonstrated to be associated with tumour progression. However, the different subpopulations of TILs and their roles in breast cancer remain poorly understood. Large-scale analysis using multiomics data could uncover potential mechanisms and provide promising biomarkers for predicting immunotherapy response.

Methods

Single-cell transcriptome data for breast cancer samples were analysed to identify unique TIL subsets. Based on the expression profiles of marker genes in these subsets, a TIL-related prognostic model was developed by univariate and multivariate Cox analyses and LASSO regression for the TCGA training cohort containing 1089 breast cancer patients. Multiplex immunohistochemistry w

SUBMITTER: Xia ZA 

PROVIDER: S-EPMC10367329 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature