Genomic analysis and prediction of genomic values for distichiasis in Staffordshire bull terriers.

ABSTRACT:

Background

Distichiasis is a condition characterized by aberrant hairs along the eyelid margins. The symptoms are usually mild but can lead to ulcerations and lesions of the cornea in severe cases. It is the most frequently noted ocular disorder in Norwegian Staffordshire bull terriers (SBT), with a prevalence above 18% in the adult population. A complex inheritance is assumed, but there is sparse knowledge about the genetic background of distichiasis in dogs. We have performed a genome-wide association study of distichiasis in SBT and used genomic data in an attempt to predict genomic values for the disorder.

Results

We identified four genetic regions on CFA1, CFA18, CFA32 and CFA34 using a mixed linear model association analysis and a Bayesian mixed model analysis. Genomic

SUBMITTER: Jorgensen D 

PROVIDER: S-EPMC10367371 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature