Interleukin-1β inhibitors for the management of acute gout flares: a systematic literature review.

ABSTRACT:

Objectives

The objective of this systematic review was to assess the effects of interleukin-1β (IL-1β) inhibitors on gout flares.

Methods

Studies published between 2011 and 2022 that evaluated the effects of IL-1β inhibitors in adult patients experiencing gout flares were eligible for inclusion. Outcomes including pain, frequency and intensity of gout flares, inflammation, and safety were assessed. Five electronic databases (Pubmed/Medline, Embase, Biosis/Ovid, Web of Science and Cochrane Library) were searched. Two independent reviewers performed study screening, data extraction and risk of bias assessments (Cochrane Risk of Bias Tool 2 for randomised controlled trials [RCTs] and Downs and Black for non-RCTs). Data are reported as a narrative synthesis.

Results

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SUBMITTER: Schlesinger N 

PROVIDER: S-EPMC10367374 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature