Mortality risk in patients with anti-MDA5 dermatomyositis is related to rapidly progressive interstitial lung disease and anti-Ro52 antibody.

ABSTRACT:

Background

This study aimed to describe the clinical characteristics and analyze the poor prognostic factors in patients with anti-MDA5 dermatomyositis.

Methods

A total of 126 adults with anti-MDA5 dermatomyositis were enrolled in this retrospective study. Information on survival time, cause of death, and baseline characteristics was collected. Patients were divided into two groups: a survival group and a non-survival group. Items with clinical significance that showed significant differences between the two groups were screened by Kaplan-Meier and Cox regression analyses to identify the predictors of poor survival.

Results

Thirty-two patients were included in the non-survival group, most of whom died from respiratory failure, with pulmonary infection accounting for h

SUBMITTER: Wang H 

PROVIDER: S-EPMC10367378 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature