Pyroptosis -related potential diagnostic biomarkers in steroid-induced osteonecrosis of the femoral head.

ABSTRACT:

Purpose

Steroid-induced necrosis of the femoral head (SONFH) is a refractory orthopedic hip disease occurring in young and middle-aged people, with glucocorticoids being the most common cause. Previous experimental studies have shown that cell pyroptosis may be involved in the pathological process of SONFH, but its pathogenesis in SONFH is still unclear. This study aims to screen and validate potential pyroptosis-related genes in SONFH diagnosis by bioinformatics analysis to further elucidate the mechanism of pyroptosis in SONFH.

Methods

There were 33 pyroptosis-related genes obtained from the prior reviews. The mRNA expression was downloaded from GSE123568 dataset in the Gene Expression Omnibus (GEO) database, including 10 non-SONFH (following steroid administration) sample

SUBMITTER: Chai JL 

PROVIDER: S-EPMC10367407 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature