Synthesis of picolinates via a cooperative vinylogous anomeric-based oxidation using UiO-66(Zr)-N(CH₂PO₃H₂)₂ as a catalyst.

ABSTRACT: The anomeric effect highlights the significant influence of the functional group and reaction conditions on oxidation-reduction. This article successfully investigates the anomeric effect in the synthesis of picolinate and picolinic acid derivatives through a multi-component reaction involving 2-oxopropanoic acid or ethyl 2-oxopropanoate, ammonium acetate, malononitrile, and various aldehydes. To facilitate this process, we employed UiO-66(Zr)-N(CH₂PO₃H₂)₂ as a novel nanoporous heterogeneous catalyst. The inclusion of phosphorous acid tags on the UiO-66(Zr)-N(CH₂PO₃H₂)₂ offers the potential for synthesizing picolinates at ambient temperature.

SUBMITTER: Babaee S 

PROVIDER: S-EPMC10368083 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature