Development of o-aminobenzamide salt derivatives for improving water solubility and anti-undifferentiated gastric cancer.

ABSTRACT: Background: Gastric cancer is one of the cancers with wide incidence, difficult treatment and high mortality in the world, especially in Asia and Africa. In our previous work, a novel o-aminobenzamide analogue F8 was identified as an early preclinical candidate for treatment of undifferentiated gastric cancer (IC₅₀ of 0.26 μM for HGC-27). However, the poor water solubility of compound F8 prevents its further progress in preclinical studies. Aim: To improve the water solubility and drug-likeness of F8 via salt formation. Method: Different acids and F8 were reacted to obtain different salt forms. Physicochemical property screening, pharmacokinetic property research, and antitumor biological activity evaluation in vitro

SUBMITTER: Li S 

PROVIDER: S-EPMC10368370 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature