Accumulation in Visceral Adipose Tissue Over 6 Years Is Associated With Lower Paraspinal Muscle Density.

ABSTRACT:

Context

Visceral adipose tissue (VAT) has been recognized to be a metabolically active fat depot that may have paracrine effects on surrounding tissues, including muscle. Since many adults accumulate VAT as they age, the effect of changes in VAT on muscle is of interest.

Objective

We determined the association between 6-year changes in VAT and paraspinal muscle density, an indicator of fatty infiltration.

Methods

This study included 1145 participants from the Framingham Study third-generation cohort who had both quantitative computed tomography scans of the spine at baseline and 6-year's follow-up, on whom muscle density was measured along with VAT. We implemented multiple regression to determine the association of muscle density at follow-up as primary outcome measur

SUBMITTER: Liu CT 

PROVIDER: S-EPMC10368410 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature