Lipid homeostasis is essential for a maximal ER stress response.

ABSTRACT: Changes in lipid metabolism are associated with aging and age-related diseases, including proteopathies. The endoplasmic reticulum (ER) is uniquely a major hub for protein and lipid synthesis, making its function essential for both protein and lipid homeostasis. However, it is less clear how lipid metabolism and protein quality may impact each other. Here, we identified let-767, a putative hydroxysteroid dehydrogenase in Caenorhabditis elegans, as an essential gene for both lipid and ER protein homeostasis. Knockdown of let-767 reduces lipid stores, alters ER morphology in a lipid-dependent manner, and blocks induction of the Unfolded Protein Response of the ER (UPR^ER). Interestingly, a global reduction in lipogenic pathways restores UPR^ER inducti

SUBMITTER: Garcia G 

PROVIDER: S-EPMC10368420 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature