Body surface potential mapping detects early disease onset in plakophilin-2-pathogenic variant carriers.

ABSTRACT:

Aims

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive inherited cardiac disease. Early detection of disease and risk stratification remain challenging due to heterogeneous phenotypic expression. The standard configuration of the 12 lead electrocardiogram (ECG) might be insensitive to identify subtle ECG abnormalities. We hypothesized that body surface potential mapping (BSPM) may be more sensitive to detect subtle ECG abnormalities.

Methods and results

We obtained 67 electrode BSPM in plakophilin-2 (PKP2)-pathogenic variant carriers and control subjects. Subject-specific computed tomography/magnetic resonance imaging based models of the heart/torso and electrode positions were created. Cardiac activation and recovery patterns were visualized with QRS-

SUBMITTER: Kloosterman M 

PROVIDER: S-EPMC10368448 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature