Role of Human Epicardial Adipose Tissue-Derived miR-92a-3p in Myocardial Redox State.

ABSTRACT:

Background

Visceral obesity is directly linked to increased cardiovascular risk, including heart failure.

Objectives

This study explored the ability of human epicardial adipose tissue (EAT)-derived microRNAs (miRNAs) to regulate the myocardial redox state and clinical outcomes.

Methods

This study screened for miRNAs expressed and released from human EAT and tested for correlations with the redox state in the adjacent myocardium in paired EAT/atrial biopsy specimens from patients undergoing cardiac surgery. Three miRNAs were then tested for causality in an in vitro model of cardiomyocytes. At a clinical level, causality/directionality were tested using genome-wide association screening, and the underlying mechanisms were explored using human biopsy specimens, as well a

SUBMITTER: Carena MC 

PROVIDER: S-EPMC10368522 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature