Global emergence of carbapenem-resistant Klebsiella pneumoniae co-carrying multiple carbapenemases.

ABSTRACT: The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) co-carrying multiple carbapenemases is complicating clinical treatment. This study aimed to investigate the global dissemination trends of CRKP strains that co-carry multiple carbapenemases. The CRKP isolate KP424 co-carrying bla_NDM-1 and bla_KPC-2, recovered from a stool specimen, was identified by the NG-Test Carba 5 test, and the genome sequence was further determined by using Nanopore MinION and Illumina NovaSeq 6000 technologies. The genome sequences of the CRKP strains carrying multiple carbapenemase genes were further retrieved from the NCBI GenBank database. Thirteen antimicrobial resistance genes, including bla_NDM-1 and bla_KPC-2, have bee

SUBMITTER: Guo H 

PROVIDER: S-EPMC10368534 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature