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Integration of nuclear Ca²⁺ transients and subnuclear protein shuttling provides a novel mechanism for the regulation of CREB-dependent gene expression.

ABSTRACT: Nuclear Ca²⁺ waves elicited by NMDAR and L-type voltage-gated Ca²⁺-channels as well as protein transport from synapse-to-nucleus are both instrumental in control of plasticity-related gene expression. At present it is not known whether fast [Ca²⁺]_n transients converge in the nucleus with signaling of synapto-nuclear protein messenger. Jacob is a protein that translocate a signalosome from N-methyl-D-aspartate receptors (NMDAR) to the nucleus and that docks this signalosome to the transcription factor CREB. Here we show that the residing time of Jacob in the nucleoplasm strictly correlates with nuclear [Ca²⁺]_n transients elicited by neuronal activity. A steep increase in [Ca²⁺]_n induces instantaneous unc

SUBMITTER: Karpova A

PROVIDER: S-EPMC10368568 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Integration of nuclear Ca²⁺ transients and subnuclear protein shuttling provides a novel mechanism for the regulation of CREB-dependent gene expression.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Integration of nuclear Ca2+ transients and subnuclear protein shuttling provides a novel mechanism for the regulation of CREB-dependent gene expression.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Integration of nuclear Ca²⁺ transients and subnuclear protein shuttling provides a novel mechanism for the regulation of CREB-dependent gene expression.