Plasma microRNA ratios associated with breast cancer detection in a nested case-control study from a mammography screening cohort.

ABSTRACT: Mammographic breast cancer screening is effective in reducing breast cancer mortality. Nevertheless, several limitations are known. Therefore, developing an alternative or complementary non-invasive tool capable of increasing the accuracy of the screening process is highly desirable. The objective of this study was to identify circulating microRNA (miRs) ratios associated with BC in women attending mammography screening. A nested case-control study was conducted within the ANDROMEDA cohort (women of age 46-67 attending BC screening). Pre-diagnostic plasma samples, information on life-styles and common BC risk factors were collected. Small-RNA sequencing was carried out on plasma samples from 65 cases and 66 controls. miR ratios associated with BC were selected by two-sample Wilcoxon test a

SUBMITTER: Chiorino G 

PROVIDER: S-EPMC10368693 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature