Assessment of infant outgrowth of cow's milk allergy in relation to the faecal microbiome and metaproteome.

ABSTRACT: Previous studies provide evidence for an association between modifications of the gut microbiota in early life and the development of food allergies. We studied the faecal microbiota composition (16S rRNA gene amplicon sequencing) and faecal microbiome functionality (metaproteomics) in a cohort of 40 infants diagnosed with cow's milk allergy (CMA) when entering the study. Some of the infants showed outgrowth of CMA after 12 months, while others did not. Faecal microbiota composition of infants was analysed directly after CMA diagnosis (baseline) as well as 6 and 12 months after entering the study. The aim was to gain insight on gut microbiome parameters in relation to outgrowth of CMA. The results of this study show that microbiome differences related to outgrowth of CMA can be mainly iden

SUBMITTER: Hendrickx DM 

PROVIDER: S-EPMC10368738 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature