Deciphering the genetic basis of immune thrombocytopenia: current evidence for genetic predisposition in adult ITP.

ABSTRACT: Immune thrombocytopenia (ITP) is the consequence of a complex, still incompletely understood immunological dysregulation. Proposed mechanisms include autoantibody-induced platelet destruction, impaired platelet production as well as abnormalities in T-cell immunity, such as T helper cells (Th1) polarization, a high proportion of Th17 cells, and a reduced number of regulatory T cells. Although the etiology of ITP is incompletely understood and considered multifactorial in most cases, genetic variants are thought to play a key role in susceptibility to ITP, especially in persistent or chronic ITP. Efforts are currently underway to uncover possible predisposing genetic factors for the development of ITP. Single-nucleotide polymorphisms and copy number variations have been identified in severa

SUBMITTER: Georgi JA 

PROVIDER: S-EPMC10368779 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature