Development of lumen-based perfusable 3D liver in vitro model using single-step bioprinting with composite bioinks.

ABSTRACT: Hepatic sinusoids are uniquely organized structures that help maintain a spectrum of hepatic functions. Although several in vitro liver models have been developed to replicate liver sinusoids, most of these platforms require complex, multi-step fabrication methods making it difficult to achieve truly three-dimensional (3D) channel geometries. In this study, a single-step bioprinting technique was demonstrated to simultaneously print a chip platform and develop a perfusable vascularized liver sinusoid in vitro model. The integrated system uses a co-axial-based bioprinting approach to develop a liver sinusoid-like model that consists of a sacrificial core compartment containing a perfusable pre-vascular structure and an alginate-collagen-based shell compartment containing hepatocytes. The lu

SUBMITTER: Maji S 

PROVIDER: S-EPMC10368928 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature