Combination of HBA1, TTR, and SERPINF2 in plasma defines phenotype correlated with severe burn outcome.

ABSTRACT: Recent advancements in proteomics allow for the concurrent identification and quantification of multiple proteins. This study aimed to identify proteins associated with severe burn pathology and establish a clinically useful molecular pathology classification. In a retrospective observational study, blood samples were collected from severe burn patients. Proteins were measured using mass spectrometry, and prognosis-related proteins were extracted by comparing survivors and non-survivors. Enrichment and ROC analyses evaluated the extracted proteins, followed by latent class analysis. Measurements were performed on 83 burn patients. In the non-survivor group, ten proteins significantly changing on the day of injury were associated with metabolic processes and toxin responses. ROC analysis id

SUBMITTER: Onishi S 

PROVIDER: S-EPMC10368932 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature