A pyroptosis-related gene signature that predicts immune infiltration and prognosis in colon cancer.

ABSTRACT:

Background

Colon cancer (CC) is a highly heterogeneous malignancy associated with high morbidity and mortality. Pyroptosis is a type of programmed cell death characterized by an inflammatory response that can affect the tumor immune microenvironment and has potential prognostic and therapeutic value. The aim of this study was to evaluate the association between pyroptosis-related gene (PRG) expression and CC.

Methods

Based on the expression profiles of PRGs, we classified CC samples from The Cancer Gene Atlas and Gene Expression Omnibus databases into different clusters by unsupervised clustering analysis. The best prognostic signature was screened and established using least absolute shrinkage and selection operator (LASSO) and multivariate COX regression analyses. Subseque

SUBMITTER: Wu M 

PROVIDER: S-EPMC10369052 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature