Mediation of lateral hypothalamus orexin input to lateral habenula in the inhibitory effects of mechanical stimulation on psychomotor responses induced by cocaine.

ABSTRACT:

Introduction

The lateral hypothalamus (LH) plays an important physiological role in brain function and also plays an important role in substance abuse. The neuropeptides called orexin (or hypocretins) have been identified as being located exclusively in the cell bodies of the LH. Our previous studies have demonstrated that mechanical stimulation (MS) of the ulnar nerve produces strong inhibitory effects on cocaine addiction-like behaviors through activation of LH projection to the lateral habenula (LHb).

Methods

Therefore, the present study hypothesized that ulnar MS would suppress the psychomotor responses induced by cocaine through the orexinergic LH-to-LHb pathway.

Results

Ulnar MS attenuated cocaine enhancement of locomotor activity and 50-kHz ultrasonic vocalizat

SUBMITTER: Jang HB 

PROVIDER: S-EPMC10369078 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature