Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations.

ABSTRACT:

Objective

South Asians are diagnosed with type 2 diabetes (T2D) more than a decade earlier in life than seen in European populations. We hypothesized that studying the genomics of age of diagnosis in these populations may give insight into the earlier age diagnosis of T2D among individuals of South Asian descent.

Research design and methods

We conducted a meta-analysis of genome-wide association studies (GWAS) of age at diagnosis of T2D in 34,001 individuals from four independent cohorts of European and South Asian Indians.

Results

We identified two signals near the TCF7L2 and CDKAL1 genes associated with age at the onset of T2D. The strongest genome-wide significant variants at chromosome 10q25.3 in TCF7L2 (rs7903146; P = 2.4 × 10-12, β = -0.436; SE 0.02) and chromos

SUBMITTER: Srinivasan S 

PROVIDER: S-EPMC10369131 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature