The relationship between cytochrome c oxidase, CBF and CMRO₂ in mouse cortex: A NIRS-MRI study.

ABSTRACT: Quantifying relationships between cerebral blood flow (CBF), mitochondrial function (cytochrome c oxidase oxidation state), and metabolic rate of oxygen (CMRO₂) could provide useful insight into normal neurovascular coupling, as well as regulation of oxidative metabolism in neurological disorders. This paper uses a multimodal NIRS-MRI method to quantify these parameters in rodent brain and, in so doing, provides novel information on the regulation of oxygen metabolism by stimulating with hypercapnia or variations in oxygenation. Under hypercapnia, although oxygenation, oxidation state, and CBF increased, there was no increase in CMRO₂. Also, there was no correlation between CBF and CCO oxidation state. Conversely, changing oxygenation resulted in a strong correlation

SUBMITTER: Hashem M 

PROVIDER: S-EPMC10369142 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature