Superior sagittal sinus flow as a proxy for tracking global cerebral blood flow dynamics during wakefulness and sleep.

ABSTRACT: Sleep, a state of reduced consciousness, affects brain oxygen metabolism and lowers cerebral metabolic rate of oxygen (CMRO₂). Previously, we quantified CMRO₂ during sleep via Fick's Principle, with a single-band MRI sequence measuring both hemoglobin O₂ saturation (SvO₂) and superior sagittal sinus (SSS) blood flow, which was upscaled to obtain total cerebral blood flow (tCBF). The procedure involves a brief initial calibration scan to determine the upscaling factor (f_c), assumed state-invariant. Here, we used a dual-band sequence to simultaneously provide SvO₂ in SSS and tCBF in the neck every 16 seconds, allowing quantification of f_c dynamically. Ten healthy subjects were scanned by MRI with simultaneous EEG fo

SUBMITTER: Caporale AS 

PROVIDER: S-EPMC10369151 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature