The PANoptosis-related signature indicates the prognosis and tumor immune infiltration features of gliomas.

ABSTRACT:

Background

Gliomas are the most common primary tumors of the central nervous system, with high heterogeneity and highly variable survival rates. Accurate classification and prognostic assessment are key to the selection of treatment strategies. One hallmark of the tumor is resistance to cell death. PANoptosis, a novel mode of programmed cell death, has been frequently reported to be involved in the innate immunity associated with pathogen infection and played an important role in cancers. However, the intrinsic association of PANoptosis with glioma requires deeper investigation.

Methods

The genetics and expression of the 17 reported PANoptosome-related genes were analyzed in glioma. Based on these genes, patients were divided into two subtypes by consensus clustering analysi

SUBMITTER: Song J 

PROVIDER: S-EPMC10369193 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature