Unlocking Genetic Profiles with a Programmable DNA-Powered Decoding Circuit.

ABSTRACT: Human genetic architecture provides remarkable insights into disease risk prediction and personalized medication. Advances in genomics have boosted the fine-mapping of disease-associated genetic variants across human genome. In healthcare practice, interpreting intricate genetic profiles into actionable medical decisions can improve health outcomes but remains challenging. Here an intelligent genetic decoder is engineered with programmable DNA computation to automate clinical analyses and interpretations. The DNA-based decoder recognizes multiplex genetic information by one-pot ligase-dependent reactions and interprets implicit genetic profiles into explicit decision reports. It is shown that the DNA decoder implements intended computation on genetic profiles and outputs a corresponding an

SUBMITTER: Liu J 

PROVIDER: S-EPMC10369254 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature