Outcomes of Isocitrate Dehydrogenase Wild Type Glioblastoma after Re-irradiation.

ABSTRACT:

Purpose

Glioblastomas (GBM) are the most common malignant primary brain tumors in adults and have a dismal prognosis. Patients frequently suffer from local tumor recurrences, with limited therapeutic options. Re-irradiation represents a possible intervention, but given the recent 5th edition of the World Health Organization classification of central nervous system tumors, studies in isocitrate dehydrogenase wild type (IDH-wt) cohorts undergoing a second course of radiotherapy remain limited. Herein, we sought to describe our institutional experience and outcomes after GBM IDH-wt re-irradiation.

Materials and methods

GBM patients with confirmed IDH-wt status undergoing re-irradiation were included in this single-center, retrospective analysis.

Results

A total of 88 pat

SUBMITTER: Ehret F 

PROVIDER: S-EPMC10369398 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature