Mechanistic Studies of Iron-PyBOX-Catalyzed Olefin Amino-Oxygenation with Functionalized Hydroxylamines.

ABSTRACT: Iron-catalyzed amino-oxygenation of olefins often uses discrete ligands to increase reactivity and broaden substrate scope. This work is focused on examining ligand effects on reactivity and in situ iron speciation in a system which utilizes a bisoxazoline ligand. Freeze-trapped ⁵⁷Fe Mössbauer and EPR spectroscopies as well as SC-XRD experiments were utilized to isolate and identify the species formed during the catalytic reaction of amino-oxygenation of olefins with functionalized hydroxylamines, as well as in the precatalytic mixture of iron salt and ligand. Experiments revealed significant influence of ligand and solvent on the speciation in the precatalytic mixture which led to the formation of different species which had significant influence on the reactivity. In situ expe

SUBMITTER: Radovic A 

PROVIDER: S-EPMC10369677 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature