A novel immunohistochemical score predicts the postoperative prognosis of gastric cancer patients.

ABSTRACT:

Background and aim

Immunohistochemistry indicators are increasingly being used to predict the survival prognosis of cancer patients after surgery. This study aimed to combine some markers to establish an immunohistochemical score (MSI-P53-Ki-67[MPK]) and stratify postoperative patients with gastric cancer according to the score.

Methods

We used 245 patients who underwent surgery at one center as the training cohort and 111 patients from another center as the validation cohort. All patients were treated between January 2012 and June 2018. The training cohort was screened for prognostic factors, and MPK scores were established using univariate and multifactorial COX risk proportional models. Patients were prognostically stratified according to the MPK score after gastrectomy f

SUBMITTER: Liu F 

PROVIDER: S-EPMC10369746 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature