Assessment of bidirectional relationships between brain imaging-derived phenotypes and stroke: a Mendelian randomization study.

ABSTRACT:

Background

Stroke is a major cause of mortality and long-term disability worldwide. Whether the associations between brain imaging-derived phenotypes (IDPs) and stroke are causal is uncertain.

Methods

We performed two-sample bidirectional Mendelian randomization (MR) analyses to explore the causal associations between IDPs and stroke. Summary data of 587 brain IDPs (up to 33,224 individuals) from the UK Biobank and five stroke types (sample size range from 301,663 to 446,696, case number range from 5,386 to 40,585) from the MEGASTROKE consortium were used.

Results

Forward MR indicated 14 IDPs belong to projection fibers or association fibers were associated with stroke. For example, higher genetically determined mean diffusivity (MD) in the right external capsule was

SUBMITTER: Yu K 

PROVIDER: S-EPMC10369749 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature