Effects of human probiotics on memory and psychological and physical measures in community-dwelling older adults with normal and mildly impaired cognition: results of a bi-center, double-blind, randomized, and placebo-controlled clinical trial (CleverAge biota).

ABSTRACT:

Objectives

This study presents results of our randomized clinical trial studying the effect of human probiotics on memory and psychological and physical measures following our study protocol registered at clinicaltrials.gov NCT05051501 and described in detail in our previous paper.

Methods

Community dwelling participants aged between 55 and 80  years were randomly assigned to receive a single dose of 10⁶ colony-forming units of human Streptococcus thermophilus GH, Streptococcus salivarius GH NEXARS, Lactobacilus plantarum GH, and Pediococcus pentosaceus GH or placebo. A cross-over design allowed each group to receive probiotics and placebo for 3  months each in reverse order. A small subset of participants was examined online due to the COVID-

SUBMITTER: Bartos A 

PROVIDER: S-EPMC10369778 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature