Darier's disease exhibits a unique cutaneous microbial dysbiosis associated with inflammation and body malodour.

ABSTRACT:

Background

Darier's disease (DD) is a genodermatosis caused by mutations of the ATP2A2 gene leading to disrupted keratinocyte adhesion. Recurrent episodes of skin inflammation and infections with a typical malodour in DD indicate a role for microbial dysbiosis. Here, for the first time, we investigated the DD skin microbiome using a metabarcoding approach of 115 skin swabs from 14 patients and 14 healthy volunteers. Furthermore, we analyzed its changes in the context of DD malodour and the cutaneous DD transcriptome.

Results

We identified a disease-specific cutaneous microbiome with a loss of microbial diversity and of potentially beneficial commensals. Expansion of inflammation-associated microbes such as Staphylococcus aureus and Staphylococcus warneri strongly correlated

SUBMITTER: Amar Y 

PROVIDER: S-EPMC10369845 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature