NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy.

ABSTRACT: Meningiomas are the most common primary intracranial tumors^1-3. Treatments for patients with meningiomas are limited to surgery and radiotherapy, and systemic therapies remain ineffective or experimental^4,5. Resistance to radiotherapy is common in high-grade meningiomas⁶, and the cell types and signaling mechanisms driving meningioma tumorigenesis or resistance to radiotherapy are incompletely understood. Here we report NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy and find NOTCH3+ meningioma mural cells are conserved across meningiomas from humans, dogs, and mice. NOTCH3+ cells are restricted to the perivascular niche during meningeal development and homeostasis and in low-grade meningiomas but are expressed throughout high-grade me

SUBMITTER: Choudhury A 

PROVIDER: S-EPMC10369862 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature