Insulin alleviates murine colitis through microbiome alterations and bile acid metabolism.

ABSTRACT:

Background

Insulin has been reported to exhibit anti-inflammatory activities in the context of bowel inflammation. However, the role of the interaction between insulin and the microbiota in gut health is unclear. Our goal was to investigate the mechanism of action of insulin in bowel inflammation and the relationship between insulin and the gut microbiota.

Methods

We used acute and chronic murine models of inflammatory bowel disease (IBD) to evaluate whether insulin influences the progression of colitis. Colonic tissues, the host metabolome and the gut microbiome were analyzed to investigate the relationship among insulin treatment, the microbiome, and disease. Experiments involving antibiotic (Abx) treatment and fecal microbiota transplantation (FMT) confirmed the associati

SUBMITTER: He S 

PROVIDER: S-EPMC10369930 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature