The contribution of gene flow, selection, and genetic drift to five thousand years of human allele frequency change.

ABSTRACT: Genomic time series from experimental evolution studies and ancient DNA datasets offer us a chance to directly observe the interplay of various evolutionary forces. We show how the genome-wide variance in allele frequency change between two time points can be decomposed into the contributions of gene flow, genetic drift, and linked selection. In closed populations, the contribution of linked selection is identifiable because it creates covariances between time intervals, and genetic drift does not. However, repeated gene flow between populations can also produce directionality in allele frequency change, creating covariances. We show how to accurately separate the fraction of variance in allele frequency change due to admixture and linked selection in a population receiving gene flow. We u

SUBMITTER: Simon A 

PROVIDER: S-EPMC10370008 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature