Contact area and tissue growth dynamics shape synthetic juxtacrine signaling patterns.

ABSTRACT: Cell-cell communication through direct contact, or juxtacrine signaling, is important in development, disease, and many areas of physiology. Synthetic forms of juxtacrine signaling can be precisely controlled and operate orthogonally to native processes, making them a powerful reductionist tool with which to address fundamental questions in cell-cell communication in vivo. Here we investigate how cell-cell contact length and tissue growth dynamics affect juxtacrine signal responses through implementing a custom synthetic gene circuit in Drosophila wing imaginal discs alongside mathematical modeling to determine synthetic Notch (synNotch) activation patterns. We find that the area of contact between cells largely determines the extent of synNotch activation, leading to the prediction that t

SUBMITTER: Dawson J 

PROVIDER: S-EPMC10370035 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature