Inflammasomes primarily restrict cytosolic <i>Salmonella</i> replication within human macrophages.

ABSTRACT: Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that utilizes its type III secretion systems (T3SSs) to inject virulence factors into host cells and colonize the host. In turn, a subset of cytosolic immune receptors respond to T3SS ligands by forming multimeric signaling complexes called inflammasomes, which activate caspases that induce interleukin-1 (IL-1) family cytokine release and an inflammatory form of cell death called pyroptosis. Human macrophages mount a multifaceted inflammasome response to Salmonella infection that ultimately restricts intracellular bacterial replication. However, how inflammasomes restrict Salmonella replication remains unknown. We find that caspase-1 is essential for mediating inflammasome responses to S

SUBMITTER: Egan MS 

PROVIDER: S-EPMC10370064 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature