Elastic fibers define embryonic tissue stiffness to enable buckling morphogenesis of the small intestine.

ABSTRACT: During embryonic development, tissues must possess precise material properties to ensure that cell-generated forces give rise to the stereotyped morphologies of developing organs. However, the question of how material properties are established and regulated during development remains understudied. Here, we aim to address these broader questions through the study of intestinal looping, a process by which the initially straight intestinal tube buckles into loops, permitting ordered packing within the body cavity. Looping results from elongation of the tube against the constraint of an attached tissue, the dorsal mesentery, which is elastically stretched by the elongating tube to nearly triple its length. This elastic energy storage allows the mesentery to provide stable compressive forces t

SUBMITTER: Loffet EA 

PROVIDER: S-EPMC10370103 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature