Resting EEG Periodic and Aperiodic Components Predict Cognitive Decline Over 10 Years.

ABSTRACT: Measures of intrinsic brain function at rest show promise as predictors of cognitive decline in humans, including EEG metrics such as individual alpha peak frequency (IAPF) and the aperiodic exponent, reflecting the strongest frequency of alpha oscillations and the relative balance of excitatory:inhibitory neural activity, respectively. Both IAPF and the aperiodic exponent decrease with age and have been associated with worse executive function and working memory. However, few studies have jointly examined their associations with cognitive function, and none have examined their association with longitudinal cognitive decline rather than cross-sectional impairment. In a preregistered secondary analysis of data from the longitudinal Midlife in the United States (MIDUS) study, we tested wheth

SUBMITTER: Finley AJ 

PROVIDER: S-EPMC10370116 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature