Stem cell transcriptional profiles from mouse subspecies reveal <i>cis</i> -regulatory evolution at translation genes.

ABSTRACT: A key goal of evolutionary genomics is to harness molecular data to draw inferences about selective forces that have acted on genomes. The field progresses in large part through the development of advanced molecular-evolution analysis methods. Here we explored the intersection between classical sequence-based tests for selection and an empirical expression-based approach, using stem cells from Mus musculus subspecies as a model. Using a test of directional, cis -regulatory evolution across genes in pathways, we discovered a unique program of induction of translation genes in stem cells of the Southeast Asian mouse M. m. castaneus relative to its sister taxa. We then mined population-genomic sequences to pursue underlying regulatory mechanisms for this expression diverg

SUBMITTER: Simon NM 

PROVIDER: S-EPMC10370129 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature