Gene expression variation underlying tissue-specific responses to copper stress in Drosophila melanogaster.

ABSTRACT: Copper is one of a handful of biologically necessary heavy metals that is also a common environmental pollutant. Under normal conditions, copper ions are required for many key physiological processes. However, in excess, copper quickly results in cell and tissue damage that can range in severity from temporary injury to permanent neurological damage. Because of its biological relevance, and because many conserved copper-responsive genes also respond to other non-essential heavy metal pollutants, copper resistance in Drosophila melanogaster is a useful model system with which to investigate the genetic control of the response to heavy metal stress. Because heavy metal toxicity has the potential to differently impact specific tissues, we genetically characterized the control of the ge

SUBMITTER: Everman ER 

PROVIDER: S-EPMC10370140 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature