A natural bacterial pathogen of <i>C. elegans</i> uses a small RNA to induce transgenerational inheritance of learned avoidance.

ABSTRACT: Previously, we discovered that a small RNA from a clinical isolate of Pseudomonas aeruginosa, PA14, induces learned avoidance and its transgenerational inheritance in C. elegans. Pseudomonas aeruginosa is an important human pathogen, and there are other Pseudomonads in C. elegans' natural habitat, but it is unclear whether C. elegans ever encounters PA14-like bacteria in the wild. Thus, it is not known if small RNAs from bacteria found in C. elegans' natural habitat can also regulate host behavior and produce heritable behavioral effects. Here we found that a pathogenic Pseudomonas vranovensis strain isolated from the C. elegans microbiota, GRb0427, like PA14, regulates worm behavior: worms learn to avoid this pathogenic bacter

SUBMITTER: Sengupta T 

PROVIDER: S-EPMC10370180 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature