Transcriptomic changes in oligodendrocytes and precursor cells predicts clinical outcomes of Parkinson's disease.

ABSTRACT: Several prior studies have proposed the involvement of various brain regions and cell types in Parkinson's disease (PD) pathology. Here, we performed snRNA-seq on the prefrontal cortex and anterior cingulate regions from post-mortem control and PD brain tissue. We found a significant association of oligodendrocytes (ODCs) and oligodendrocyte precursor cells (OPCs) with PD-linked risk loci and report several dysregulated genes and pathways, including regulation of tau-protein kinase activity, regulation of inclusion body assembly and protein processing involved in protein targeting to mitochondria. In an independent PD cohort with clinical measures (681 cases and 549 controls), polygenic risk scores derived from the dysregulated genes significantly predicted Montreal Cognitive Assessment (M

SUBMITTER: Dehestani M 

PROVIDER: S-EPMC10370193 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature