Cell division angle regulates the tissue mechanics and tunes the amount of cerebellar folding.

ABSTRACT: Modeling has proposed that the amount of neural tissue folding is set by the level of differential-expansion between tissue layers and that the wavelength is set by the thickness of the outer layer. Here we used inbred mouse strains with distinct amounts of cerebellar folding to investigate these predictions. We identified a critical period where the folding amount diverges between the strains. In this period, regional changes in the level of differential-expansion between the external granule layer (EGL) and underlying core correlate with the folding amount in each strain. Additionally, the thickness of the EGL is regionally adjusted during the critical period alongside corresponding changes in wavelength. While the number of SHH-expressing Purkinje cells predicts the folding amount, the

SUBMITTER: Cook AG 

PROVIDER: S-EPMC10370211 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature