The effect of combining antibiotics on resistance: A systematic review and meta-analysis.

ABSTRACT: When and under which conditions antibiotic combination therapy decelerates rather than accelerates resistance evolution is not well understood. We examined the effect of combining antibiotics on within-patient resistance development across various bacterial pathogens and antibiotics. We searched CENTRAL, EMBASE and PubMed for (quasi)-randomised controlled trials (RCTs) published from database inception to November 24^th, 2022. Trials comparing antibiotic treatments with different numbers of antibiotics were included. A patient was considered to have acquired resistance if, at the follow-up culture, a resistant bacterium (as defined by the study authors) was detected that had not been present in the baseline culture. We combined results using a random effects model and performed m

SUBMITTER: Siedentop B 

PROVIDER: S-EPMC10370225 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature